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Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
Methylene blue has been used as a placebo; physicians would tell their patients to expect their urine to change color and view this as a sign that their condition had improved. [26] This same side effect makes methylene blue difficult to use in traditional placebo-controlled clinical studies, including those testing for its efficacy as a treatment.
Greenish urine can result from the consumption of asparagus or foods, [citation needed] beverages with green pigments, or from a urinary tract infection. [8] Blue urine can be caused by the ingestion of methylene blue (e.g., in medications) or foods or beverages with blue dyes. Blue urine stains can be caused by blue diaper syndrome.
A spectrum of abnormal colors can result from the intake of drugs. An unusually bright yellow color can occur after consumption of B vitamin supplements, [31] while phenazopyridine, used to treat urinary tract-related pain, can turn the urine orange. Methylene blue may turn it blue to bluish-green. [32]
Emphysematous cystitis is a rare type of infection of the bladder wall by gas-forming bacteria or fungi.The most frequent offending organism is E. coli.Other gram negative bacteria, including Klebsiella and Proteus are also commonly isolated.
Uromune, also known by its developmental code name MV-140, is a polyvalent bacterial vaccine which is used and is being developed for prevention of recurrent urinary tract infections (UTIs). [ 1 ] [ 2 ] [ 3 ] In clinical studies , it has been found to reduce total number of UTIs by about 70%, to increase UTI-free rates from around 25% to 57% ...
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