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“In short if you have this gene and someone does not, it could be speculated that you will one, have more energy than them, and two, be able to burn more fat into working energy rather than ...
Joint instability and soft tissue injuries: Dislocations, subluxations, or damage to muscles, ligaments, tendons, synovium, or cartilage as a result of excessive joint movement. Chronic pain : Recurrent joint pain that can develop into hyperalgesia , with a higher rate of small fiber neuropathy in some individuals.
Starvation response in animals (including humans) is a set of adaptive biochemical and physiological changes, triggered by lack of food or extreme weight loss, in which the body seeks to conserve energy by reducing metabolic rate and/or non-resting energy expenditure to prolong survival and preserve body fat and lean mass.
Abnormal joint proprioception (an impaired ability to locate body parts in space and/or monitor an extended joint) These abnormalities cause abnormal joint stress, meaning that the joints can wear out, leading to osteoarthritis. The condition tends to run in families, suggesting a genetic basis for at least some forms of hypermobility.
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However, genes that promote only limited fat deposition in the context of pre-industrialized lifestyles and diets may promote excessive fat deposition and obesity when caloric intake is increased and expenditure is decreased beyond the range of the environments these genes evolved in (a gene x environment interaction).
Lipedema is a condition that is almost exclusively found in women [3] and results in enlargement of both legs due to deposits of fat under the skin. [2] Women of any weight may be affected [2] [3] and the fat is resistant to traditional weight-loss methods. [4]
Early on, there may be distal laxity (hypermobility), but all of those with Bethlem myopathy eventually develop multiple joint contractures: long finger flexors, wrists, elbows, hips, knees and ankles. [5] [11] There may also be club foot, scoliosis or rigid spine.