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Catabolite Activator Protein (blue) bound to a piece of DNA (red). In cell biology, catabolite activator protein (CAP), which is also known as cAMP receptor protein (CRP), is a trans-acting transcriptional activator in bacteria that effectively catalyzes the initiation of DNA transcription by interacting with RNA polymerase in a way that causes the DNA to bend.
The Association for Molecular Pathology (abbreviated AMP) is a professional association of individuals serving patients through molecular diagnostics testing. Founded in 1995, the Association has more than 3,100 members in over 50 countries.
The College of American Pathologists (CAP) is a member-based physician organization founded in 1946 comprising approximately 18,000 board-certified pathologists. It serves patients, pathologists, and the public [ 1 ] by fostering and advocating best practices in pathology and laboratory medicine.
In 2013, Batut et al. [13] combined CAP trapper, template switching, and 5′-phosphate-dependent exonuclease digestion in RAMPAGE to maximize promoter specificity. In 2014, Murata et al. [ 14 ] published the nAnTi-CAGE protocol, where capped 5′ ends are sequenced on the Illumina platform with no PCR amplification and no tag cleavage.
This recruitment to the m7G 5′ cap is supported by the inability of eukaryotic ribosomes to translate circular mRNA, which has no 5′ end. [14] Once the PIC binds to the mRNA it scans until it reaches the first AUG codon in a Kozak sequence. [15] [16] This scanning is referred to as the scanning mechanism of initiation.
In molecular biology, the five-prime cap (5′ cap) is a specially altered nucleotide on the 5′ end of some primary transcripts such as precursor messenger RNA.This process, known as mRNA capping, is highly regulated and vital in the creation of stable and mature messenger RNA able to undergo translation during protein synthesis.
This phenomenon, the process of which is called cap formation, was discovered in 1971 on lymphocytes [1] and is a property of amoebae and all locomotory animal cells except sperm. The crosslinking is most easily achieved using a polyvalent antibody to a surface antigen on the cell.
Navacaprant (developmental code names include BTRX-335140, BTRX-140, CYM-53093, NMRA-335140, and NMRA-140), is a selective κ-opioid receptor antagonist which is under development for the treatment of major depressive disorder.