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Paroxetine, sold under the brand name Paxil among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [7] used to treat major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and premenstrual dysphoric disorder. [7]
(mg/day) [4] ~80% SERT occupancy (mg/day) [5] [6] Ratio (dosage / 80% occupancy) Citalopram: 20–40: 40: 0.5–1 Escitalopram: 10–20: 10: 1–2 Fluoxetine: 20–80: 20: 1–4 Fluvoxamine: 50–350: 70: 0.71–5 Paroxetine: 10–60: 20: 0.5–3 Sertraline: 25–200: 50: 0.5–4 Duloxetine: 20–120: 30: 0.67–2 Venlafaxine: 75–375: 75: 1 ...
The following 6 pages use this file: Antidepressant; Development and discovery of SSRI drugs; List of phenyltropanes; Paroxetine; Selective serotonin reuptake inhibitor; Substituted methylenedioxyphenethylamine
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
This is a list of psychiatric medications used by psychiatrists and other physicians to treat mental illness or distress.. The list is ordered alphabetically according to the condition or conditions, then by the generic name of each medication.
Water pills Methylene blue If you have a history of heart problems — such as QT prolongation and heart rhythm disturbance — you should talk to your healthcare provider before taking escitalopram.
Since mono-substitution in the 4-para position of the phenoxy group (figure 4) results in selective inhibition of 5-HT re-uptake, a disubstitution i.e. 2,3- or 2,4- substitution therefore results in a loss of SERT selectivity. [6] Fluoxetine has the widest spectrum of activity since it is the least SERT selective of all the SSRIs.
Paroxetine may produce discontinuation-related symptoms at a greater rate than other SSRIs, though qualitatively similar effects have been reported for all SSRIs. [ 181 ] [ 182 ] Discontinuation effects appear to be less for fluoxetine, perhaps owing to its long half-life and the natural tapering effect associated with its slow clearance from ...