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TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells [6] and platelets. [7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1 , E-selectin , and ICAM-1 through a p38 -dependent mechanism.
ANGPT1, ANGPT2, and ANGPT4 activate TIE-2. Intracellular signal transduction can proceed via DOK-R (yellow arrow) or alternatively via Akt to eNOS (orange arrow). The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2 ...
Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...
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The general format of EDIF involves using parentheses to delimit data definitions, and in this way it superficially resembles Lisp.The basic tokens of EDIF 2.0.0 were keywords (like library, cell, instance, etc.), strings (delimited with double quotes), integer numbers, symbolic constants (e.g. GENERIC, TIE, RIPPER for cell types) and "Identifiers", which are reference labels formed from a ...
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