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Risedronic acid, often used as its sodium salt risedronate sodium, is a bisphosphonate. [1] It slows down the cells which break down bone. [ 1 ] It's used to treat or prevent osteoporosis , and treat Paget's disease of bone . [ 1 ]
Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [4]
[3] [4] Risedronate has also been shown to reduce the risk of hip fractures. [5] [6] After five years of medications by mouth or three years of intravenous medication among those at low risk, bisphosphonate treatment can be stopped. [13] In those at higher risk ten years of medication by mouth or six years of intravenous treatment may be used. [13]
Examples of bisphosphonates: : Zoledronic acid (Reclast, Zometa), Risedronate (Actonel), Alendronate (Fosamax), Etidronate (Didronel), Ibandronate (Boniva), Pamidronate (Aredia), Tiludronate (Skelid). [32] Denosumab. Denosumab is a monoclonal antibody [33] [34] which is administrated subcutaneously. It inhibits osteoclast differentiation and ...
Studies on risedronate analogous with different placement of nitrogen on the ring have shown no measurable difference on biological activity. Increased length of carbon chain connected to the ring revealed negative results. [18] Zoledronate is the most potent bisphosphonate drug today only available as intravenous injection.
The diet must ensure optimal calcium intake (of at least one gram daily) and measuring vitamin D levels is recommended, and to take specific supplements if necessary. [123] Osteoporosis can affect nearly 1 in 3 women and the bone loss is the most rapid within the first 2–3 years after menopause.