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Risedronic acid, often used as its sodium salt risedronate sodium, is a bisphosphonate. [1] It slows down the cells which break down bone. [1] It's used to treat or prevent osteoporosis, and treat Paget's disease of bone. [1] It is taken by mouth. [1] It was patented in 1984 and approved for medical use in 1998. [2]
[3] [4] Risedronate has also been shown to reduce the risk of hip fractures. [5] [6] After five years of medications by mouth or three years of intravenous medication among those at low risk, bisphosphonate treatment can be stopped. [13] In those at higher risk ten years of medication by mouth or six years of intravenous treatment may be used. [13]
Studies on risedronate analogous with different placement of nitrogen on the ring have shown no measurable difference on biological activity. Increased length of carbon chain connected to the ring revealed negative results. [18] Zoledronate is the most potent bisphosphonate drug today only available as intravenous injection.
Risedronate sodium tablet taken once daily for 2 months is the prescribed regimen; patients should wait at least 30 minutes after taking before eating any food, drinking anything other than tap water, taking any medication, or lying down (patient may sit). Zoledronic acid is given as an intravenous infusion; a single dose is effective for two ...
The likelihood of this condition developing varies widely from less than 1/10,000 to 1/100, as many other factors need to be considered, such as the type, dose and frequency of intake of drug, how long it has been taken for, and why it has been taken. [56] In patients taking drugs for cancer, the likelihood of MRONJ development varies from 0 - 12%.
In 2008, the US Food and Drug Administration (FDA) issued a communication warning of the possibility of severe and sometimes incapacitating bone, joint or muscle pain. [8] A study conducted by the American Society of Bone and Mineral Research concluded that long-term use of bisphosphonates, including Boniva, may increase the risk of a rare but serious fracture of the femur. [9]
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
In fact footnote [1] contradicts what this article says: "In women who have already been diagnosed with low bone density putting them at risk for fracture or have already had a fracture in the bones of their spine, risedronate: - probably prevents fractures in the bones of the spine and in bones other than in the spine; - may prevent hip ...