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NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms.
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. [5] Function
50508 224480 Ensembl ENSG00000074771 ENSMUSG00000023802 UniProt Q9HBY0 Q672J9 RefSeq (mRNA) NM_015718 NM_198958 RefSeq (protein) NP_056533 NP_945196 Location (UCSC) Chr 6: 155.4 – 155.46 Mb Chr 17: 3.69 – 3.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NADPH oxidase 3 is an enzyme that in humans is encoded by the NOX3 gene. Function NADPH oxidases, such as NOX3, are plasma ...
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP [1] [2] or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source'). NADPH is the reduced form, whereas NADP + is the ...
NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene). [5] The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS).
Respiratory burst requires a 10 to 20 fold increase in oxygen consumption through NADPH oxidase (NOX2 in humans) activity. NADPH is the key substrate of NOX2, and bears reducing power. Glycogen breakdown is vital to produce NADPH. This occurs via the pentose phosphate pathway.
NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene. [5] NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene. [6]
n/a Ensembl ENSG00000255346 n/a UniProt Q96PH1 n/a RefSeq (mRNA) NM_001184779 NM_001184780 NM_024505 n/a RefSeq (protein) NP_001171708 NP_001171709 NP_078781 n/a Location (UCSC) Chr 15: 68.93 – 69.06 Mb n/a PubMed search n/a Wikidata View/Edit Human NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene. Function NOX5 is ...