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The gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G protein-coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase, which induce synthesis of intracellular cAMP. The A 2A receptor binds with the G s protein at the intracellular site of ...
Caffeine keeps you awake by blocking adenosine receptors. Each type of adenosine receptor has different functions, although with some overlap. [3] For instance, both A 1 receptors and A 2A play roles in the heart, regulating myocardial oxygen consumption and coronary blood flow, while the A 2A receptor also has broader anti-inflammatory effects throughout the body. [4]
A 2A receptor antagonists may prevent hepatic cirrhosis, and pentoxifylline may inhibit phosphodiesterase and provide renal protection. [6]The A 2A receptor antagonists may be used for treatment of attention deficit hyperactivity disorder (), because of the receptors ability to regulate neurotransmission in the basal ganglia and cortex, particularly dopaminergic and glutamatergic signaling.
150 11551 Ensembl ENSG00000150594 ENSMUSG00000033717 UniProt P08913 Q01338 RefSeq (mRNA) NM_000681 NM_007417 RefSeq (protein) NP_000672 NP_031443 Location (UCSC) Chr 10: 111.08 – 111.08 Mb Chr 19: 54.03 – 54.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The alpha-2A adrenergic receptor (α 2A adrenoceptor), also known as ADRA2A, is an α 2 adrenergic receptor, and also ...
The alpha-2 (α 2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the G i heterotrimeric G-protein. It consists of three highly homologous subtypes, including α 2A-, α 2B-, and α 2C-adrenergic. Some species other than humans express a fourth α 2D-adrenergic receptor as well. [1]
8590 18317 Ensembl ENSG00000184933 ENSMUSG00000070417 UniProt O95222 n/a RefSeq (mRNA) NM_003696 NM_010983 RefSeq (protein) NP_003687 n/a Location (UCSC) Chr 11: 6.79 – 6.8 Mb Chr 7: 106.59 – 106.61 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene. It is Class II (tetrapod -specific) olfactory receptor ...
The gene therapy will compete with Australia-based CSL Behring’s Hemgenix, a similar treatment that won FDA approval for hemophilia B in 2022. That drug has a similar list price of $3.5 million ...
In ex vivo gene therapies, such as CAR-T therapeutics, the patient's own cells (autologous) or healthy donor cells (allogeneic) are modified outside the body (hence, ex vivo) using a vector to express a particular protein, such as a chimeric antigen receptor. [62] In vivo gene therapy is seen as simpler, since it does not require the harvesting ...