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Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. [10] [11] Raised blood pressure is notable. [23] Rare but serious side effects include seizures, [10] [11] liver toxicity, [24] psychosis, [25] and risk of overdose. [26]
Abnormal dreams; Aggression; Anaphylactic shock; Angioedema (indicative of a hypersensitivity reaction); Arthralgia; Ataxia; Blood glucose disturbances; Bronchospasm (indicative of a hypersensitivity reaction)
Sustained-release versions of bupropion (Wellbutrin SR, for example) can contain 100 mg, 150 mg or 200 mg. Extended-release tablets of bupropion contain either 150 mg or 300 mg.
Bupropion, on the other hand, is one of the few antidepressants that don’t cause these common side effects, and some research shows it can have the opposite effect — increasing your libido.
The FDA added a black box warning — the most prominent drug safety warning — to bupropion packaging alerting healthcare providers and patients about potentially dangerous side effects.
[2] [3] It is taken as a tablet by mouth. [1] Side effects of dextromethorphan/bupropion include dizziness, headache, diarrhea, somnolence, dry mouth, sexual dysfunction, and hyperhidrosis, among others. [1] The mechanism of action of dextromethorphan/bupropion in the treatment of depression is unknown. [1]
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