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Ankylosing spondylitis (AS) is a type of arthritis from the disease spectrum of axial spondyloarthritis. [5] It is characterized by long-term inflammation of the joints of the spine, typically where the spine joins the pelvis. [2] With AS, eye and bowel problems—as well as back pain—may occur. [2]
The spectrum of axial involvement includes true ankylosing spondylitis, which is characterized by classic clinical and radiologic features, as well as asymptomatic sacroiliitis and inflammatory pain in the lower back regardless of the radiological evidence of the condition. Axial involvement may occur years before bowel disease.
Microscopically visible ileal inflammation is seen in about 50% of people with spondyloarthritis and ankylosing spondylitis during ileocolonoscopy. [11] [4] There seems to be an immunological connection between the gut inflammation observed in Crohn's disease and ankylosing spondylitis. [12]
Since the disease ankylosing spondylitis was still defined by the Modified New York criteria of 1984, there was the need to find a new disease term that would also include the less severe forms or early onset of ankylosing spondylitis. This expression was found in the umbrella term axial spondyloarthritis.
When involving inflammation, it can be called spondylitis. In contrast, a spondyloarthropathy is a condition involving the vertebral joints, but many conditions involve both spondylopathy and spondyloarthropathy. Examples include ankylosing spondylitis and spondylosis.
Axial spondyloarthritis (including ankylosing spondylitis) – this involves the spine, although an RA-like symmetrical small-joint polyarthritis may occur in the context of this condition. Hepatitis C – RA-like symmetrical small-joint polyarthritis may occur in the context of this condition. Hepatitis C may also induce rheumatoid factor auto ...
Ankylosing spondylitis is a type of arthritis in which there is long-term inflammation of the joints of the spine. [2] Other forms of arthritis may sometimes also lead to ankylosis, including rheumatoid arthritis and reactive arthritis; Osteoarthritis usually confers osteophyte formation, which may eventually fuse across joints. Osteoarthritis ...
Some conditions which biologics are used to treat are rheumatic disorders [3] such as psoriatic arthritis, [4] ankylosing spondylitis and non-radiographic axial spondyloarthritis, [5] and inflammatory bowel disease. [6]