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Finasteride is a 5α-reductase inhibitor and therefore an antiandrogen. [10] It works by decreasing the production of dihydrotestosterone (DHT) by about 70%. [6] In addition to DHT, finasteride also inhibits the production of several anticonvulsant neurosteroids including allopregnanolone, androstanediol, and tetrahydrodeoxycorticosterone. [11]
Circulating DHT levels in eugonadal men are about 7- to 10-fold lower than those of testosterone, and plasma levels of testosterone and DHT are highly correlated (correlation coefficient of 0.7). [ 5 ] [ 7 ] In contrast to the circulation however, levels of DHT in the prostate gland are approximately 5- to 10-fold higher than those of ...
Finasteride (brand names Proscar, Propecia) inhibits the function of two of the isoenzymes (types 2 and 3) of 5α-reductase. [6] [7] It decreases circulating DHT levels by up to about 70%. [8] Dutasteride (brand name Avodart) inhibits all three 5α-reductase isoenzymes and can decrease DHT levels by 95%.
Some studies show it can reduce DHT but doesn’t help with hair growth. Other studies show that topical finasteride is as effective as oral finasteride after 18 months of treatment.
Make sure to take finasteride for three to six months before you assess any improvements in your hair, as it may take this long for finasteride tablets to reduce the DHT levels enough for your ...
Finasteride Months 1 to 3: Finasteride Starts Working. As soon as your body begins to metabolize finasteride, it will start to reduce the amount of DHT that circulates in your bloodstream.