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STAT5 has been found to be constitutively phosphorylated in cancer cells, [4] implying that the protein is always present in its active form. This constant activation is brought about either by mutations or by aberrant expressions of cell signalling, resulting in poor regulation, or complete lack of control, of the activation of transcription ...
Cancer is a genus of marine crabs in the family Cancridae. It includes eight extant species and three extinct species, including familiar crabs of the littoral zone , such as the European edible crab ( Cancer pagurus ), the Jonah crab ( Cancer borealis ) and the red rock crab ( Cancer productus ).
SP initiates expression of almost all known immunological chemical messengers . [20] [21] [22] Also, most of the cytokines, in turn, induce SP and the NK1 receptor. [23] [24] SP is particularly excitatory to cell growth and multiplication, [25] via usual, [26] as well as oncogenic drivers. [27] SP is a trigger for nausea and emesis. [28]
Margaret ("Peggy") A. Goodell (born March 23, 1965) is an American scientist working in the field of stem cell research. Dr. Goodell is Chair of the Department of Molecular and Cellular Biology [1] at Baylor College of Medicine, Director of the Stem Cell and Regenerative Medicine (STaR) Center, [2] and a member of the National Academy of Medicine. [3]
NT5E contains binding sites for transcription factors AP-2, SMAD proteins, SP-1 and elements responsive to c-AMP, which can be found in c-AMP promoter parts.SMADs 2, 3, 4 and 5 and SP-1 are binding to the NT5E promoter in rats, as was proven in chromatin immunoprecipitation assays.
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