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Studies with infants and adults have shown that foods or drinks enriched with galactooligosaccharides result in a significant increase in Bifidobacteria. [1] These sugars can be found naturally in human milk, known as human milk oligosaccharides. [5] Examples include lacto-N-tetraose, lacto-N-neotetraose, and lacto-N-fucopentaose. [6]
These oligosaccharides pass undigested through the stomach and small intestine. In the large intestine, they are fermented by bacteria that do possess the α-GAL enzyme and make short-chain fatty acids (SCFA)(acetic, propionic, butyric acids), as well as the flatulence commonly associated with eating beans and other vegetables.
Human milk is an example of this and contains oligosaccharides, known as human milk oligosaccharides (HMOs), which are derived from lactose. [21] [22] These oligosaccharides have biological function in the development of the gut flora of infants. Examples include lacto-N-tetraose, lacto-N-neotetraose, and lacto-N-fucopentaose.
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Some FODMAPs, such as fructose, are readily absorbed in the small intestine of humans via GLUT receptors. [19] Absorption thus depends on the appropriate expression and delivery of these receptors in the intestinal enterocyte to both the apical surface, contacting the lumen of the intestine (e.g., GLUT5), and to the basal membrane, contacting the blood (e.g., GLUT2). [19]
Human milk oligosaccharides (HMOs), also known as human milk glycans, are short polymers of simple sugars that can be found in high concentrations in human breast milk. [1] Human milk oligosaccharides promote the development of the immune system, can reduce the risk of pathogen infections and improve brain development and cognition. [ 1 ]
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