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Inhaled short-acting β2-adrenergic agonists, such as terbutaline and salbutamol, are the first-line drugs indicated for asthma exacerbation for all patients to provide rapid bronchodilating effects. [ 1 ] [ 2 ] Short-acting β2-adrenergic agonists can be delivered by different devices, for example, nebulizers and metered-dose inhalers .
If high doses were used for six to 10 days, reduce to replacement dose immediately and taper over four more days. Adrenal recovery can be assumed to occur within two to four weeks of completion of steroids. If high doses were used for 11–30 days, cut immediately to twice replacement, and then by 25% every four days.
Fluticasone furoate, as an inhaled corticosteroid (ICS), can cause side effects that are characteristic of corticosteroids, such as decreased bone mineral density, adrenal suppression (decreased production of corticosteroids in the body), and a weakened immune system. [4]
[2] [specify] Using the spray or inhaler at higher than recommended doses or with other corticosteroids can increase the risk for serious, systemic corticosteroid induced side effects. [2] [3] These side effects include weakened immune system, increased risk of systemic infections, osteoporosis, and elevated pressure in the eyes. [19]
Fluticasone Furoate falls under the drug class of Corticosteroid. Corticosteroids are a class of steroid hormones produced naturally by the adrenal cortex, which is located on top of the kidneys. They play a crucial role in regulating various physiological processes in the body, including metabolism, immune response, and inflammation.
Use of corticosteroids has numerous side-effects, some of which may be severe: Severe amoebic colitis: Fulminant amoebic colitis is associated with high case fatality and can occur in patients infected with the parasite Entamoeba histolytica after exposure to corticosteroid medications. [19]
Serious side effects include an increased risk of infection, cataracts, Cushing's syndrome, and severe allergic reactions. [1] Long-term use of the pill form may cause adrenal insufficiency. [4] The pills may also cause mood or personality changes. [4] The inhaled form is generally regarded as safe in pregnancy. [6]
The most common side effects include headache, oral candidiasis, cough, and difficulty speaking. [2] Salbutamol/budesonide was approved for medical use in the United States in January 2023. [2] [3] It is the first combination of an inhaled corticosteroid and a short-acting beta-agonist to be approved by the US Food and Drug Administration (FDA ...