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Grapefruit–drug interactions that affect the pre-systemic metabolism (i.e., the metabolism that occurs before the drug enters the blood) of drugs have a different duration of action than interactions that work by other mechanisms, such as on absorption, discussed below.
Blood pressure drugs aren't the only commonly prescribed medications that grapefruit juice can mess with — they also include anticoagulants that help prevent blood clots, organ-transplant ...
In the past it was called the pomelo, [3] but that term is now mostly used as the common name for Citrus maxima. [4] Grapefruit–drug interactions are common, as the juice contains furanocoumarins that interfere with the metabolism of many drugs. This can prolong and intensify the effects of those drugs, leading to multiple side-effects such ...
The pomelo, while not itself toxic, can cause adverse interactions similar to those caused by the grapefruit with a wide range of prescription drugs. These occur by the inhibition of cytochrome P450 -mediated metabolism of prescription drugs including for example some anti-hypertensives , some anticoagulants , some anticancer agents , some anti ...
With more than 2,500 types of citrus worldwide, it would be a shame to limit your larder to lemons and limes. Luckily, many grocers also stock seasonal stunners like Sumo mandarins, yuzu, and pomelos.
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In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs .