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Granulosa cell tumours are tumours that arise from granulosa cells.They are estrogen-secreting tumours and present as large, complex, ovarian masses. These tumours are part of the sex cord–gonadal stromal tumour or non-epithelial group of tumours.
A very rare tumour producing both ovarian (granulosa and/or theca) and testicular (Sertoli and/or Leydig) cells or tissues. Typically it consists of adult-type granulosa cells and Sertoli cells, [4] [5] but it has been reported with juvenile-type granulosa cells. [6] It has been reported to occur in the ovary usually, rarely in the testis. [7]
The granulosa cells are usually arranged haphazardly around the space. They are pathognomonic for granulosa cell tumors. Histologically, these tumors consists of monotonous islands of granulosa cells with "coffee-bean" nuclei. That same nuclear groove appearance noted in Brenner tumour, an epithelial-stromal ovarian tumor distinguishable by ...
Adult granulosa cell tumors are characterized by later onset (30+ years, 50 on average). These tumors produce high levels of estrogen, which causes its characteristic symptoms: menometrorrhagia; endometrial hyperplasia; tender, enlarged breasts; postmenopausal bleeding; and secondary amenorrhea.
In medicine, Meigs's syndrome, also Meigs syndrome or Demons–Meigs syndrome, is the triad of ascites, pleural effusion, and benign ovarian tumor (ovarian fibroma, fibrothecoma, Brenner tumour, and occasionally granulosa cell tumour). [1] [2] [3] Meigs syndrome resolves after the resection of the tumor. Because the transdiaphragmatic lymphatic ...
Cell culture of granulosa cells can be performed in vitro. Plating density (number of cells per volume of culture medium) plays a critical role for the differentiation. A lower plating density makes granulosa cells exhibit estrogen production, while a higher plating density makes them appear as progesterone producing theca lutein cells. [12]
Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time. It is also known as Abrikossoff's tumor , [ 1 ] granular cell myoblastoma , [ 1 ] granular cell nerve sheath tumor , [ 1 ] and granular cell schwannoma . [ 1 ]
Histologically, there are nests of transitional epithelial cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma. The coffee bean nuclei are the nuclear grooves exceptionally pathognomonic to the sex cord stromal tumour, the ovarian granulosa cell tumour, with the fluid-filled spaces Call–Exner bodies ...