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Starved for oxygen and nutrients, elastic fibers become patchy and smooth muscle cells die. If the disease progresses, syphilitic aortitis leads to an aortic aneurysm. Overall, tertiary syphilis is a rare cause of aortic aneurysms. [3] Syphilitic aortitis has become rare in the developed world with the advent of penicillin treatments after ...
In terms of the cause of aortic regurgitation, is often due to the aortic root dilation (annuloaortic ectasia), which is idiopathic in over 80% of cases, but otherwise may result from aging, syphilitic aortitis, osteogenesis imperfecta, aortic dissection, Behçet's disease, reactive arthritis and systemic hypertension. [1]
Aortitis is most commonly seen in patients with syphilis, autoimmune vasculitis (giant cell arteritis, Takayasu's arteritis), polymyalgia rheumatica, and rheumatoid arthritis. [2] IgG4-related disease has more recently been identified as a cause of aortitis, and also as a cause of periaortitis (inflammation surrounding the aorta). [3]
Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.
Syphilis is closely related but distinct from two other subspecies or lineages of treponemal disease, nonsexually transmitted illnesses that have similar symptoms that are known as bejel and yaws ...
Specific infective causes associated with aneurysm include: Advanced syphilis infection resulting in syphilitic aortitis and an aortic aneurysm; Tuberculosis, causing Rasmussen's aneurysms; Brain infections, causing infectious intracranial aneurysms; A minority of aneurysms are associated with genetic factors. Examples include:
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Tabes dorsalis is caused by demyelination by advanced syphilis infection (tertiary syphilis) when the primary infection by the causative spirochete bacterium, Treponema pallidum, is left untreated for an extended period of time (past the point of blood infection by the organism). [3]