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Oct-4 is one of the transcription factors that is used to create induced pluripotent stem cells (iPSCs), together with Sox2, Klf4, and often c-Myc (OSKM) in mice, [19] [20] [21] demonstrating its capacity to induce an embryonic stem-cell-like state.
Thomson et al. demonstrated that LIN28 is a factor in iPSC generation in combination with OCT4, SOX2, and NANOG. [18] Glis1: Glis1 is transcription factor that can be used with Oct-3/4, Sox2 and Klf4 to induce pluripotency. It poses numerous advantages when used instead of C-myc. [31]
In an experiment involving mouse embryonic stem cells, it was discovered that Sox2 in conjunction with Oct4, c-Myc and Klf4 were sufficient for producing induced pluripotent stem cells. [11] The discovery that expression of only four transcription factors was necessary to induce pluripotency allowed future regenerative medicine research to be ...
Virally induced expression of four transcription factors Oct4, Sox2, c-Myc, and Klf4 (Yamanaka factors) is sufficient to create pluripotent (iPS) cells from adult fibroblasts. [5] A multipotent cell is one that can differentiate into multiple different, but closely related cell types. [6]
Takahashi and Yamanaka were the first to identify KLF4 as one of four factors ( oct-3/4 + sox2 + Klf4 + c-Myc) that are required to induce mouse embryonic and adult fibroblasts into pluripotent stem cells (iPS). [22] This was also found to be true for adult human fibroblasts. [21]
[KLF4] is one of the so-called magic four transcription factors, KLF4, Oct4, Sox2 and Myc. KLF5, like KLF3, is important in adipocytes [11] and KLF6 is an important tumour suppressor gene, that is often mutated in prostate cancers. [12]
Human dermal fibroblasts → multilineage blood progenitors (Oct4 and cytokine treatment) [2] Mouse dermal fibroblasts → polygonal hyaline chondrogenic cells (Klf4, c-Myc, Sox9) [3] Mouse dermal fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and Bmp4) [4] Fibroblasts → neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4) [5]
In a study done by Chronis et al. (2017), it was found that during the reprogramming of somatic cells into pluripotent stem cells, OSK (three of the four Yamanaka factors – Oct4, Sox2, KLF4, c-Myc) works together with other transcription factors to change the enhancer landscape, leading to the loss of differentiation and the gain of ...