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A mitogenic growth factor activity was found in pituitary extracts by Armelin in 1973 [14] and further work by Gospodarowicz as reported in 1974 described a more defined isolation of proteins from cow brain extract which, when tested in a bioassay that caused fibroblasts to proliferate, led these investigators to apply the name "fibroblast ...
Growth factor is sometimes used interchangeably among scientists with the term cytokine. [3] Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes).
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [ 5 ] [ 6 ] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins , themselves a family of closely related molecules.
Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. [7] Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.
8074 64654 Ensembl ENSG00000118972 ENSMUSG00000000182 UniProt Q9GZV9 Q9EPC2 RefSeq (mRNA) NM_020638 NM_022657 RefSeq (protein) NP_065689 NP_073148 Location (UCSC) Chr 12: 4.37 – 4.38 Mb Chr 6: 127.05 – 127.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates ...
14177 Ensembl ENSG00000111241 ENSMUSG00000000183 UniProt P10767 P21658 RefSeq (mRNA) NM_020996 NM_010204 RefSeq (protein) NP_066276 NP_034334 Location (UCSC) Chr 12: 4.43 – 4.45 Mb Chr 6: 126.99 – 127.01 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene. The protein encoded by this gene is a member ...
Pages for logged out editors learn more. Contributions; Talk; Fibroblast growth factors
This article is about the role of fibroblast growth factor signaling in mesoderm formation.. Mesoderm formation is a complex developmental process involving an intricate network of signaling pathways that coordinate their activities to ensure that a selective group of cells will eventually give rise to mesodermal tissues in the adult organism.