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The marrow adipose tissue depot is poorly understood in terms of its physiologic function and relevance to bone health. Marrow adipose tissue expands in states of low bone density but additionally expands in the setting of obesity. [4] Marrow adipose tissue response to exercise approximates that of white adipose tissue.
Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes. [1] [2] It also contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages.
White adipose tissue or white fat is one of the two types of adipose tissue found in mammals. The other kind is brown adipose tissue. White adipose tissue is composed of monolocular adipocytes. In humans, the healthy amount of white adipose tissue varies with age, but composes between 6–25% of body weight in adult men and 14–35% in adult women.
In vitro studies on differentiation have used the pre-committed preadipocyte lineage, such as 3T3-L1 and 3T3-F442A cell line, or preadipocytes isolated from the stromal-vascular fraction of white adipose tissue. In vitro differentiation is a highly ordered process. Firstly, proliferating preadipocytes arrest growth usually by contact inhibition.
The obese mouse on the left has large stores of adipose tissue. For comparison, a mouse with a normal amount of adipose tissue is shown on the right. In animals, adipose tissue, or fatty tissue is the body's means of storing metabolic energy over extended periods of time. Adipocytes (fat cells) store fat derived from the diet and from liver ...
Version of the hypothesis implicating failure to generate more adipocytes in tissue expandability. The adipose tissue expandability hypothesis posits that metabolic dysregulation that appears to be caused by excess weight, such as type 2 diabetes [1] and non-alcoholic fatty liver disease, [2] are triggered when an individual's capacity for storing excess calories in the subcutaneous adipose ...
The subcutaneous tissue (from Latin subcutaneous 'beneath the skin'), also called the hypodermis, hypoderm (from Greek 'beneath the skin'), subcutis, or superficial fascia, [2] is the lowermost layer of the integumentary system in vertebrates. [3] The types of cells found in the layer are fibroblasts, adipose cells, and macrophages.
The Journal of Clinical Investigation is a semi-monthly peer-reviewed medical journal covering biomedical research. It was established in 1924 and is published by the American Society for Clinical Investigation. Articles focus on the mechanisms of disease, with an emphasis on basic research, early-stage clinical studies in humans, and new ...