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A vial of Zofran 4 mg containing ondansetron for intravenous injection Ondansetron (marketed under the brand name Zofran) was developed in the mid-1980s by GlaxoSmithKline in London. It was granted U.S. patent protection in September 1987, [ 37 ] received a use patent June 1988, [ 38 ] and was approved by the U.S. Food and Drug Administration ...
Drug Chemical nature Receptor antagonists T 1/2 (h) Metabolism Dose; Ondansetron: Carbazole derivative 5-HT 3 receptor antagonist and weak 5-HT 4 antagonist 3.9 hours CYP1A1/2, CYP2D6, CYP 3A3/4/5: 150 μg/kg Granisetron: Indazole: 5-HT 3 receptor antagonist 9–11.6 hours CYP3A3/4/5: 10 μg/kg Dolasetron: Indole: 5-HT 3 receptor antagonist 7 ...
Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, sublingual, or in an IV/IM injection. Tropisetron (Setrovel, Navoban) can be administered in oral capsules or in injection form. Palonosetron (Aloxi) can be administered in an injection or in oral capsules.
Serotonin (5-HT3) receptor antagonists can be administered as a single dose at the end of surgery. Adverse effects include prolongation of the QT interval on electrocardiogram (EKG). Medications include ondansetron, granisetron, and dolasetron. Anticholinergics can be used as a long-acting patch placed behind the patient's ear. Adverse effects ...
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
It may be used together with ondansetron and dexamethasone. [5] It is taken by mouth [5] or administered by intravenous injection. [3] A pro-drug, fosaprepitant, is also available for intravenous administration [6].
Aprepitant has also been shown to increase the activity of the 5-HT 3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy. [11] Netupitant has recently been approved by USFDA. It has also been marketed in combination with palonosetron.
A small test dose of bleomycin is often given prior to the first round of ABVD to screen for patients who may be allergic. Neuropathy : Chemotherapy-induced peripheral neuropathy , a progressive and enduring tingling numbness, intense pain, and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs.