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In 1993, a genetic polymorphism within lipomas was localized to chromosome 12q15, where the HMGIC gene encodes the high-mobility-group protein isoform I-C. [2] This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 ...
The lipomas are well-encapsulated, slow-growing, benign fatty tumors. The distribution is defined as being focused in the trunk of the body and extremities. [2] Familial Multiple Lipomatosis can be identified when multiple lipomas occur in multiple family members that span different generations. [2] Some people may have hundreds of lipomas ...
Cutaneous lipomas are rare in children, but these tumors can occur as part of the inherited disease Bannayan-Zonana syndrome. [40] [41] Lipomas are usually relatively small with diameters of about 1–3 cm, [42] but in rare cases they can grow over several years into "giant lipomas" that are 10–20 cm across and weigh up to 4–5 kg. [43] [44]
Dercum's disease is a rare condition characterized by multiple painful fatty tumors, called lipomas, that can grow anywhere in subcutaneous fat across the body. [1] Sometimes referred as adiposis dolorosa in medical literature, Dercum’s disease is more of a syndrome than a disease (because it has several clinically recognizable features, signs, and symptoms that are characteristic of it and ...
Angiolipoma is a subcutaneous nodule with vascular structure, having all other features of a typical lipoma. They are commonly painful. [1]: 624 [2] Angiolipomas manifest as multiple painful subcutaneous nodules commonly on the upper limbs. The can occur sporadically, with a family history or after trauma.
Although they have also been reported in the head and neck, shoulder, groin, axilla, back, and abdominal cavity, these tumors typically manifest in the extremities. [10] Although it is normally painless, it may cause symptoms such as vomiting , stomach pain , paralysis , or fecal or urinary incontinence , depending on where the mass is ...
Angiomyolipoma seen as a hyperechoic mass in the upper pole of an adult kidney on renal ultrasonography. Renal ultrasonography of a person with tuberous sclerosis and multiple angiomyolipomas in the kidney: Measurement of kidney length on the US image is illustrated by '+' and a dashed line.
The histology of NLCS typically demonstrates the proliferation of ectopic mature adipocytes in the reticular dermis, which ranges from 10 to 50% of the lesion. [ 13 ] [ 14 ] Adipocytes can exist alone or in small groups between collagen bundles, but they most frequently originate surrounding blood arteries or eccrine glands .