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  2. Porphyria - Wikipedia

    en.wikipedia.org/wiki/Porphyria

    Porphyria / p ɔːr ˈ f ɪr i ə / is a group of disorders in which substances called porphyrins build up in the body, adversely affecting the skin or nervous system. [1] The types that affect the nervous system are also known as acute porphyria, as symptoms are rapid in onset and short in duration. [1]

  3. Acute intermittent porphyria - Wikipedia

    en.wikipedia.org/wiki/Acute_intermittent_porphyria

    Acute intermittent porphyria ... Physical examination often shows no abnormalities. [13] ... If drugs have caused the attack, discontinuing the offending substances ...

  4. Porphobilinogen deaminase - Wikipedia

    en.wikipedia.org/wiki/Porphobilinogen_deaminase

    The most well-known health issue involving porphobilinogen deaminase is acute intermittent porphyria, an autosomal dominant genetic disorder where insufficient hydroxymethylbilane is produced, leading to a build-up of porphobilinogen in the cytoplasm. This is caused by a gene mutation that, in 90% of cases, causes decreased amounts of enzyme.

  5. Porphyria cutanea tarda - Wikipedia

    en.wikipedia.org/wiki/Porphyria_cutanea_tarda

    Porphyria cutanea tarda is the most common subtype of porphyria. [1] The disease is named because it is a porphyria that often presents with skin manifestations later in life. The disorder results from low levels of the enzyme responsible for the fifth step in heme production. Heme is a vital molecule for all of the body's organs.

  6. Erythropoietic protoporphyria - Wikipedia

    en.wikipedia.org/wiki/Erythropoietic_protoporphyria

    Erythropoietic protoporphyria (or commonly called EPP) is a form of porphyria, which varies in severity and can be very painful.It arises from a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the red blood cells (erythrocytes), plasma, skin, and liver. [2]

  7. List of skin conditions - Wikipedia

    en.wikipedia.org/wiki/List_of_skin_conditions

    Skin conditions resulting from errors in metabolism are caused by enzymatic defects that lead to an accumulation or deficiency of various cellular components, including, but not limited to, amino acids, carbohydrates, and lipids. [16] Acute intermittent porphyria; Adrenoleukodystrophy (Schilder's disease) Alkaptonuria

  8. Aminolevulinic acid dehydratase deficiency porphyria - Wikipedia

    en.wikipedia.org/wiki/Aminolevulinic_acid_de...

    Aminolevulinic acid dehydratase deficiency porphyria (also known as Doss porphyria, [1] plumboporphyria, [1] or ADP [2]) is an extremely rare autosomal recessive metabolic disorder that results from inappropriately low levels of the enzyme delta-aminolevulinic acid dehydratase (), which is required for normal heme synthesis.

  9. Trimethoprim/sulfamethoxazole - Wikipedia

    en.wikipedia.org/wiki/Trimethoprim/sulfamethoxazole

    A Cochrane review found that while it is an effective treatment for shigellosis it also produces more significant adverse effects than other antibiotic drugs. [43] Staphylococcus aureus infections: No: No: No: In vitro and in vivo activity against both non-resistant and methicillin-resistant Staphylococcus aureus (MRSA) infections. [44] [45 ...