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The elimination rate constant K or K e is a value used in pharmacokinetics to describe the rate at which a drug is removed from the human system. [1] It is often abbreviated K or K e. It is equivalent to the fraction of a substance that is removed per unit time measured at any particular instant and has units of T −1.
That is: it is valid if it is an e-value. In fact, this reveals that e-values bounded to [, /] are rescaled randomized tests, that are continuously interpreted as evidence against the hypothesis. The standard e-value that takes value in [,] appears as a generalization of a level 0 test. [2]
The [A] at which E is 50% of E max is termed the half maximal effective concentration and is abbreviated EC 50, or rarely [A] 50. The term "potency" refers to the EC 50 value. The lower the EC 50 , the less the concentration of a drug is required to produce 50% of maximum effect and the higher the potency.
It is a reflection of the potency of a drug and is expressed in molar units such as mol/L. [31] The value of EC50 greatly depends on the affinity of the drug for its receptor, as well as the efficacy of the drug, which conveys receptor occupancy and the ability of the drug to trigger a biological response. [32]
Clearance can refer to the volume of plasma from which the substance is removed (i.e., cleared) per unit time or, in some cases, inter-compartmental clearances can be discussed when referring to redistribution between body compartments such as plasma, muscle, and fat. [2]
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The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8]
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