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The lethality of the anthrax disease is due to the bacterium's two principal virulence factors: the poly-D-glutamic acid capsule, which protects the bacterium from phagocytosis by host neutrophils; and the tripartite protein toxin, called anthrax toxin, consisting of protective antigen (PA), edema factor (EF), and lethal factor (LF). [44]
Anthrax is a disease caused by Bacillus anthracis, a spore-forming, Gram positive, rod-shaped bacterium (Fig. 1).The lethality of the disease is caused by the bacterium's two principal virulence factors: (i) the polyglutamic acid capsule, which is anti-phagocytic, and (ii) the tripartite protein toxin, called anthrax toxin.
The pXO1 plasmid (182 kb) contains the genes that encode for the anthrax toxin components: pag (protective antigen, PA), lef (lethal factor, LF), and cya (edema factor, EF). These factors are contained within a 44.8-kb pathogenicity island (PAI). The lethal toxin is a combination of PA with LF and the edema toxin is a combination of PA with EF.
Anthrax weaponization is the development and deployment of the bacterium Bacillus anthracis or, more commonly, its spore (referred to as anthrax), as a biological weapon.As a biological weapon, anthrax has been used in biowarfare and bioterrorism since 1914. [1]
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Some bacterial toxins can be used in the treatment of tumors. [4] ... exfoliative toxins that cause scalded skin syndrome, ... Anthrax toxin is composed of three ...
Anthracimycin was first noted for its potent activity against Bacillus anthracis (strain UM23C1-1), which is known to cause the human infectious disease anthrax, with a minimum inhibitory concentration (MIC) of 0.031 ug/mL.
Anthrax is a bacterial disease that is caused by Bacillus anthracis bacteria. It can infect animals when they breathe in or ingest spores in contaminated soil, plants, or water.