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The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place. [14]
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. [1] [2] It is taken orally (swallowed by mouth). [1]
A combination antibiotic is one in which two ingredients are added together for additional therapeutic effect. [1] One or both ingredients may be antibiotics. [1]Antibiotic combinations are increasingly important because of antimicrobial resistance. [2]
Sulfamethoxazole is primarily renally excreted via glomerular filtration and tubular secretion. [8] About 20% of the sulfamethoxazole in urine is the unchanged drug, about 15–20% is the N-glucuronide conjugate, and about 50–70 % is the acetylated metabolite. [11] Sulfamethoxazole is also excreted in human milk. [8]
Nitrofurantoin, trimethoprim-sulfamethoxazole (TMP/SMX), fosfomycin, and pivmecillinam are currently the first-line agents for empiric therapy of simple cystitis. [4] On the other hand, the choice of empiric antimicrobial therapy for pyelonephritis depends on the severity of illness, specific host factors, and the presence of resistant bacteria.
This is a treatment for two commonly seen pulmonary diseases, asthma and chronic obstructive pulmonary disease. β-2 adrenergic receptor agonists act as bronchodilators, having an effect of inducing bronchodilation to relieve bronchoconstriction; Inhaled corticosteroids act as anti-inflammatory drugs to decrease the inflammatory response. The ...
A dihydrofolate reductase inhibitor (DHFR inhibitor) is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate.. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic advantage.
Sulamyd, Bleph-10 Sulfadiazine: Micro-Sulfon Silver sulfadiazine: Silvadene Sulfadimethoxine: Di-Methox, Albon Sulfamethizole: Thiosulfil Forte Sulfamethoxazole: Gantanol Sulfanilimide (archaic) Sulfasalazine: Azulfidine Sulfisoxazole: Gantrisin Trimethoprim-Sulfamethoxazole (Co-trimoxazole) Bactrim, Septra Sulfonamidochrysoidine (archaic ...
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