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Targeted alpha-particle therapy (or TAT) is an in-development method of targeted radionuclide therapy of various cancers. It employs radioactive substances which undergo alpha decay to treat diseased tissue at close proximity. [1] It has the potential to provide highly targeted treatment, especially to microscopic tumour cells.
Alpha radiation is a nuclear phenomenon in which a heavy radionuclide emits an energetic alpha particle (consisting of two protons and two neutrons) and transmutes to a different radionuclide. The emitted alpha particle has a range in tissue of only 40-90 microns, which minimizes collateral damage when used for treatment purposes.
The consequences of overdiagnosis and overtreatment resulting from cancer screening can lead to a decline in quality of life, due to the adverse effects of unnecessary medication and hospitalization. [10] [12] [13] The accuracy of a cancer screening test relies on its sensitivity, and low sensitivity screening tests can overlook cancers. [10]
Baseline screening strategies consisting of brain imaging and cerebrospinal fluid (CSF) analysis have emerged as crucial components of CNS prophylaxis protocols. While CSF analysis with flow cytometry instead of cytology improves sensitivity, [ 16 ] the need for more sensitive techniques remains apparent, given the proportion of patients ...
CT of the chest, lung cancer screening protocol: 1.5 mSv: 6 months Chest X-ray: 0.1 mSv: 10 days Heart: Coronary CT angiography: 12 mSv: 4 years Coronary CT calcium scan: 3 mSv: 1 year Abdominal: CT of abdomen and pelvis: 10 mSv: 3 years CT of abdomen and pelvis, low dose protocol: 3 mSv [15] 1 year CT of abdomen and pelvis, with + without ...
Alpha Protocol is a 2010 action role-playing game developed by Obsidian Entertainment and published by Sega.The player assumes control of agent Michael Thorton, a new recruit at a clandestine United States agency called Alpha Protocol, which is given unlimited resources to conduct covert operations on behalf of the government.