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The nerve lesions in these people show dissemination in space with an otherwise normal neurological examination and without historical accounts of typical MS symptoms. [1] MRI findings that are consistent with multiple sclerosis have been observed in healthy people who underwent MRI scanning, and 50% go on to develop symptomatic MS, sometimes ...
Unusual types of MS have been described; these include Devic's disease, Balo concentric sclerosis, Schilder's diffuse sclerosis, and Marburg multiple sclerosis. There is debate on whether they are MS variants or different diseases. [31] Multiple sclerosis behaves differently in children, taking more time to reach the progressive stage. [5]
Therefore, clinically assisted diagnostic criteria are still required for a more accurate MS diagnosis than MRI alone. [97] The lesion evolution under MRI has been reported to begin as a pattern of central hyperintensity. This was seen in the majority of new lesions, both on proton density and contrast-enhanced T1-weighted images. [98]
Standard multiple sclerosis, the most known and extended variant. Devic's disease and neuromyelitis optica (NMO) (sometimes previously called optic-spinal MS) Acute disseminated encephalomyelitis or ADEM, a closely related disorder in which a known virus or vaccine triggers autoimmunity against myelin.
Contact: Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie Am Fassberg 11 37077 Göttingen Literature: Martin Uecker, Shuo Zhang, Dirk Voit, Alexander Karaus, Klaus-Dietmar Merboldt, and Jens Frahm, Real-time magnetic resonance imaging at a resolution of 20 ms, NMR in Biomedicine 23: 986–994 (2010) DOI:10.1002/nbm.1585
Tumefactive multiple sclerosis is a condition in which the central nervous system of a person has multiple demyelinating lesions with atypical characteristics for those of standard multiple sclerosis (MS). It is called tumefactive as the lesions are "tumor-like" and they mimic tumors clinically, radiologically and sometimes pathologically.
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For example, in the context of oncology, an MRI scan may reveal the shape and size of a tumor, while an MRSI study provides additional information about the metabolic activity occurring in the tumor. MRSI can be performed on a standard MRI scanner, and the patient experience is the same for MRSI as for MRI.