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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
Sirtuins are a family of signaling proteins involved in metabolic regulation. [2] [3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [2] Whereas bacteria and archaea encode either one or two sirtuins, eukaryotes encode several sirtuins in their genomes.
Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging-related diseases. [1]
[1] The main ones are histone deacetylases (HDACs) and sirtuins (SIRT1,2,3,5). [2] Because histone proteins were the first known substrate for protein deacetylases, the latter all tend to be called HDACs of one class or another. Human protein deacetylase enzymes have been categorized into Class I (HDAC1,2,3,8); Class II (HDAC4,5,6,7,9,10),
SRT-2104 is an experimental drug that was studied by Sirtris Pharmaceuticals as a small-molecule activator of the sirtuin subtype SIRT1.The compound progressed to Phase II human trials for Type II diabetes before development was discontinued, however it continues to be widely used in animal research into the functions of SIRT1.
n/a Ensembl ENSG00000284357 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 1: 9.15 – 9.15 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 34a (miR-34a) is a microRNA that in humans is encoded by the MIR34A gene. Function microRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene ...
NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [5] [6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.
Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [ 5 ] [ 6 ] [ 7 ] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation . [ 5 ]