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Fenofibrate (sold under the brand name Tricor among others), is an oral medication of the fibrate class used to treat abnormal blood lipid levels. [3] It is less commonly used compared to statins because it treats a different type of cholesterol abnormality to statins.
Fibrates improve atherogenic dyslipidemia characterized by high triglyceride and/or low HDL-C levels and elevated concentrations of small dense LDL particles, with or without high LDL-C levels. Fibrates may be compared to statin drugs, which reduce LDL-cholesterol (LDL-C) and have only limited effects on other lipid parameters.
PPARα (alpha) is the main target of fibrate drugs, a class of amphipathic carboxylic acids (clofibrate, gemfibrozil, ciprofibrate, bezafibrate, and fenofibrate). They were originally indicated for dyslipidemia of cholesterol and more recently for disorders characterized by high triglycerides.
With the safety of Tricor already proved, they hope to fast track clinical studies both in the U.S. and Israel within the next couple of weeks.After advancing 2.27% to $98.87 in Tuesday's session ...
Fortunately, high triglycerides can be addressed with diet changes, such as eating more fiber and omega-3 fatty acids, while limiting excess dietary fat and added sugars. And that’s where canned ...
It activates a type of receptor called the peroxisome proliferator-activated receptor alpha, which is involved in breaking down fat from the diet, especially triglycerides. [2] When the receptors are activated, the breakdown of fats is accelerated, and this helps clear the blood of cholesterol and triglycerides. [2]