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Sulbutiamine is used to treat asthenia (weakness), [2] though is not clear if it is effective in alleviating drowsiness. [3] It is also used to treat thiamine deficiency and poor concentration. Being a potent cholinergic , [ citation needed ] sulbutiamine is a popular nootropic , with users reporting enhanced memory, focus, and improved mood ...
Methylcobalamin is also used in the treatment of peripheral neuropathy, diabetic neuropathy, and as a preliminary treatment for amyotrophic lateral sclerosis. [ 4 ] Methylcobalamin that is ingested is not used directly as a cofactor, but is first converted by MMACHC into cob(II)alamin.
Vitamin B 12 supplements are available as single or multivitamin tablets. Pharmaceutical preparations of vitamin B 12 may be given by intramuscular injection. [6] [62] Since there are few non-animal sources of the vitamin, vegans are advised to consume a dietary supplement or fortified foods for B 12 intake, or risk serious health consequences. [6]
Cyanocobalamin is a form of vitamin B 12 used to treat and prevent vitamin B 12 deficiency except in the presence of cyanide toxicity. [7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer.
Because they are soluble in water, excess B vitamins are generally readily excreted, although individual absorption, use and metabolism may vary. [7] The elderly and athletes may need to supplement their intake of B 12 and other B vitamins due to problems in absorption and increased needs for energy production.
Eperisone hydrochloride is available as the brand name preparations Myonal and Epry as 50 mg sugar-coated tablets, or as 10% granules for oral administration. [6] An experimental form of the drug, as a transdermal patch system, has shown promising results in laboratory tests on rodents; however, this product is not currently available for human use.
Most multivitamins come in capsule form; tablets, powders, liquids, and injectable formulations also exist. In the United States, the FDA requires any product marketed as a "multivitamin" to contain at least three vitamins and minerals; furthermore, the dosages must be below a "tolerable upper limit", and a multivitamin may not include herbs ...
The EMA has concluded that the benefits of these medicines outweigh their risks, but that there is a need to limit the duration of use to ensure that the risk of patients developing liver problems is kept to a minimum. Therefore, the EMA has limited the use of systemic formulations (tablets, solutions, suppositories) of nimesulide to 15 days. [27]