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Phenacetin (/ f ɪ ˈ n æ s ɪ t ɪ n / ⓘ; acetophenetidin, N-(4-ethoxyphenyl)acetamide [1]) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, [ 2 ] and by the U.S. Food and Drug ...
Trademarked in 1918, Anacin is one of the oldest brands of pain relievers in the United States. It originally contained acetophenetidin (phenacetin) and was promoted as "aspirin-free relief," but was reformulated in the 1980s following the FDA's ruling to withdraw phenacetin from the market in 1983 due to concerns over its carcinogenic properties.
Diversion, abuse, and a relatively high rate of overdose deaths in comparison to other drugs of its group. This drug continues to be available in most of the world including the US, but under strict controls. Terfenadine (Seldane, Triludan) 1997–1998 France, South Africa, Oman, others, US Prolonged QT interval; ventricular tachycardia [2] [3]
Several such formulations have disappeared from over-the-counter status in drug store aisles and other retail outlets. One example is APC (aspirin, phenacetin, and caffeine) compound tablets common from the 1940s to 1983; because of harmful side effects of phenacetin, Anacin in the U.S. was reformulated to eliminate it; while Vincent's APC is ...
Phenylephrine ‘is extensively broken down in the liver, resulting in little to no pharmacological effect’
Compound analgesics were banned in Australia in 1979 due to analgesic nephropathy. [8] Phenacetin, a pain-relieving and fever-reducing drug, was banned by the FDA in the US in 1983, due to its adverse effects, which include kidney damage (as shown by Dr. Priscilla Kincaid-Smith) [9] [10] and cancer. [11]
The ban on specific foods in the United States can stem from a range of concerns, from animal welfare to health to mere social convention. ... Drug, and Cosmetic Act prohibits non-food items from ...
The Food and Drug Administration has banned the use of a specific red dye that has been linked to cancer in some rat studies. ... and will be free of the dye by 2026. Red No. 3 was banned in ...