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Hypolipoproteinemia, hypolipidemia, or hypolipidaemia (British English) is a form of dyslipidemia that is defined by abnormally lowered levels of any or all lipids and/or lipoproteins in the blood. It occurs in genetic disorders (e.g. hypoalphalipoproteinemia , hypobetalipoproteinemia ), malnutrition , malabsorption , wasting disease , cancer ...
Hypocholesterolemia is the presence of abnormally low (hypo-) levels of cholesterol in the blood (-emia). A defect in the body's production of cholesterol can lead to adverse consequences as well. Cholesterol is an essential component of mammalian cell membranes and is required to establish proper membrane permeability and fluidity.
Dyslipidemias can also be classified based on the underlying cause, whether it is primary, secondary, or a combination of both. [1] Primary dyslipidemias are caused by genetic disorders that can cause abnormal lipid levels without any other obvious risk factors. [1]
Many lipid storage disorders can be classified into the subgroup of sphingolipidoses, as they relate to sphingolipid metabolism. Members of this group include Niemann-Pick disease, Fabry disease, Krabbe disease, Gaucher disease, Tay–Sachs disease, metachromatic leukodystrophy, multiple sulfatase deficiency, and Farber disease.
Kidney failure is the major cause of morbidity and mortality in complete LCAT deficiency, while in partial deficiency (fish eye disease) major cause of morbidity is visual impairment due to corneal opacity. These patients have low HDL cholesterol but surprisingly premature atherosclerosis is not seen. However, there are some reported cases.
Sphingolipidoses are a class of lipid storage disorders or degenerative storage disorders caused by deficiency of an enzyme that is required for the catabolism of lipids that contain ceramide, [1] also relating to sphingolipid metabolism.
Medications that can lower vitamin D levels include laxatives, steroids and cholesterol drugs, per the Cleveland Clinic. A vitamin D deficiency is diagnosed through a blood test, says Zumpano.
These fatty substances, called lipids, include waxes, oils, and cholesterol.Three rare lipid storage diseases are caused by the deficiency of the enzyme lysosomal acid lipase: Lysosomal acid lipase deficiency (LAL-D) Wolman disease (early onset lysosomal acid lipase deficiency) Cholesteryl ester storage disease (CESD)