Ad
related to: leber's hereditary optic neuropathy eyewiki treatment system for test scores
Search results
Results From The WOW.Com Content Network
Leber's hereditary optic neuropathy (LHON) is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; it predominantly affects adult males, and onset is more likely in younger adults.
Between 1992 and 1993, in the Cuban Epidemic of Optic Neuropathy, nearly 50,000 people in Cuba were affected with optic neuropathy, sensory and autonomic peripheral neuropathy, neural deafness, and in a few cases, myelopathy. [15] [16] The most common pattern of symptoms consisted of severe weight loss, fatigue and a subacute loss of vision.
MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes) is one of the family of mitochondrial diseases, which also include MIDD (maternally inherited diabetes and deafness), MERRF syndrome, and Leber's hereditary optic neuropathy. It was first characterized under this name in 1984. [2]
Corticosteroid responsive optic neuritis not associated with demyelinating disease should also be ruled out, including sarcoidosis, systemic lupus erythematosus, or other systemic autoimmune disease. [11] Hereditary causes such as Leber's hereditary optic neuropathy are also part of the differential diagnosis. [12]
For example, clinical trials began in February 2014 to use gene therapy to treat Leber hereditary optic neuropathy, [9] which is one of the first uses of gene therapy in the central nervous system. Progress has also been made in understanding retinal ganglion cell regeneration and in re-establishing synaptic connections from the optic nerve to ...
Leber was the first to describe what is now known as Leber's congenital amaurosis in 1869 and Leber's hereditary optic neuropathy in 1871. [ 2 ] [ 3 ] [ 4 ] An anatomical structure called "Leber's plexus" is named after him, which is a small venous plexus in the eye located between Schlemm's canal (named after German anatomist Friedrich Schlemm ...
Leber's hereditary optic neuropathy (LHON) is the most frequently occurring mitochondrial disease, and this inherited form of acute or subacute vision loss predominantly affects young males. LHON usually presents with rapid vision loss in one eye followed by involvement of the second eye (usually within months).
Ageing, hereditary [2] Diagnostic method: Eye exam: Differential diagnosis: Amblyopia, retrobulbar optic neuropathy, retinitis pigmentosa sine pigmento [4] Treatment: Eyeglasses, contact lenses, refractive surgeries, IOL implantation [2] Frequency ~7.5% (US) [5]