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Red arrows indicate secreted lamellar bodies, and green arrows indicate lamellar bodies in the cytoplasm. Scale bar = 200 nm. In cell biology, lamellar bodies (otherwise known as lamellar granules, membrane-coating granules (MCGs), keratinosomes or Odland bodies) are secretory organelles found in type II alveolar cells in the lungs, and in keratinocytes in the skin.
Lamellar bodies are tubular or ovoid-shaped secretory organelles derived from the Golgi apparatus of keratinocytes in the upper part of stratum spinosum. [16] From the site of production, lamellar bodies migrate to the top of the stratum granulosum and then into the intercellular domain of the stratum corneum to extrude their contents, which ...
The Pacinian corpuscle (also lamellar corpuscle, or Vater-Pacini corpuscle) [1] is a low-threshold mechanoreceptor responsive to vibration or pressure, found in the skin and other internal organs. [2] In the skin it is one of the four main types of cutaneous receptors.
Type II cells (granulous pneumocytes) in the alveolar wall contain secretory organelles known as lamellar bodies or lamellar granules, that fuse with the cell membranes and secrete pulmonary surfactant. This surfactant is a film of fatty substances, a group of phospholipids that reduce alveolar surface tension. The phospholipids are stored in ...
A lamella (pl.: lamellae) in biology refers to a thin layer, membrane or plate of tissue. [1] This is a very broad definition, and can refer to many different structures. Any thin layer of organic tissue can be called a lamella and there is a wide array of functions an individual layer can serve.
Lamellar corpuscles, or Pacinian corpuscles or Vater-Pacini corpuscle, are deformation or pressure receptors located in the skin and also in various internal organs. [8] Each is connected to a sensory neuron. Because of its relatively large size, a single lamellar corpuscle can be isolated and its properties studied.
Lamellar bodies appear in the cytoplasm at about 20 weeks gestation. [16] These lamellar bodies are secreted by exocytosis into the alveolar lining fluid , where the surfactant forms a meshwork of tubular myelin [ 17 ] [ 18 ] Full term infants are estimated to have an alveolar storage pool of approximately 100 mg/kg of surfactant, while preterm ...
The 2013 Nobel Prize in Physiology or Medicine was shared by James Rothman, Randy Schekman and Thomas Südhof for their roles in elucidating (building upon earlier research, some of it by their mentors) the makeup and function of cell vesicles, especially in yeasts and in humans, including information on each vesicle's parts and how they are assembled.