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Epileptogenesis that occurs in human brains has been modeled in a variety of animal models and cell culture models. [2] Epileptogenesis is poorly understood, [6] and increasing understanding of the process may aid researchers in preventing seizures, diagnosing epilepsy, [23] and developing treatments to prevent it. [2]
Animal models of epilepsy have helped to advance the understanding of how normal brains develop epilepsy (a process known as Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs. [1] Epilepsy is a set of syndromes which have in common a predisposition to recurrent epileptic seizures. [2]
Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. [9] The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant number of studies on the subject of kindling ...
Epilepsy in animals is a group of neurological disorders characterized by seizures, caused by uncontrolled, abnormal bursts of electrical activity in the brain. They can start and stop very abruptly and last any amount of time from a few seconds to a few minutes. [ 1 ]
In the definition, epilepsy is now called a disease, rather than a disorder. This was a decision of the executive committee of the ILAE, taken because the word disorder , while perhaps having less stigma than does disease , also does not express the degree of seriousness that epilepsy deserves.
There are many causes of seizures. Organ failure, medication and medication withdrawal, cancer, imbalance of electrolytes, hypertensive encephalopathy , may be some of its potential causes. [ 2 ] The factors that lead to a seizure are often complex and it may not be possible to determine what causes a particular seizure, what causes it to ...
[3] [6] Unprovoked seizures have no clear cause or fixable cause. [3] [6] [7] Examples include past strokes, brain tumors, brain vessel malformations, and genetic disorders. [3] If no cause is found, it is called an idiopathic seizure. [5] [13] After a first unprovoked seizure, the chance of experiencing a second one is about 40% within 2 years.
No animal model has all the characteristics of epileptogenesis in humans, so research efforts aim to identify one. [ 22 ] [ 25 ] Such a model may help researchers find new treatments and identify the processes involved in epileptogenesis. [ 7 ]