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BRCA2 and BRCA2 (/ ˌ b r æ k ə ˈ t uː / [5]) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2 ; currently BRCA2, DNA repair associated ) are maintained by the HUGO Gene Nomenclature Committee .
Unlike other men, men with a BRCA mutation, especially a BRCA2 mutation, may benefit from professional and self breast exams. Medical imaging is not usually recommended, but because male BRCA2 carriers have a risk of breast cancer that is very similar to the general female population, the standard annual mammogram program can be adapted to ...
Men with faults in their BRCA2 gene are at higher risk of aggressive prostate cancer.
Prophylactic salpingo-oophorectomy (removal of the ovaries and fallopian tubes to prevent cancer) is recommended at age 35-40 for people with BRCA1 mutations and at age 40-45 for people with BRCA2 mutations. [6] An increasing number women who test positive for faulty BRCA1 or BRCA2 genes choose to have risk-reducing surgery. At the same time ...
BRCA1, BRCA2, HER-2, TP53, EGFR Prostate cancer ... which is a derivative of glycine, in the urine of men is correlated with metastasis of prostate cancer. ...
A BRCA2 gene mutation is associated with breast cancer, but it can also raise the risk of other cancers. Woman shares story of her pancreatic cancer diagnosis.
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The PALB2 protein acts as a hub, [13] bringing together BRCA1, BRCA2 and RAD51 at the site of a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible for RAD51 recruitment or stabilization at damage sites. [14]
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