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RNA polymerase 1 (also known as Pol I) is, in higher eukaryotes, the polymerase that only transcribes ribosomal RNA (but not 5S rRNA, which is synthesized by RNA polymerase III), a type of RNA that accounts for over 50% of the total RNA synthesized in a cell.
Antisense RNA is used for treating cancer and inhibition of metastasis and vectors for antisense sequestration. Particularly MicroRNAs(miRs) 15 and 16 to a patient in need of the treatment for diagnosis and prophylaxis of cancer. [66] Antisense drugs are based on the fact that antisense RNA hybridizes with and inactivates mRNA.
Ribonucleotide reductase and DNA polymerase inhibitor. [11] Acute lymphoblastic leukaemia and acute myeloid leukaemia: Myelosuppression, hypokalaemia, cytokine release syndrome, Stevens–Johnson syndrome (uncommon), toxic epidermal necrolysis (uncommon) and pancreatitis (uncommon) Cytarabine: SC, IM, IV, IT: DNA polymerase inhibitor, S-phase ...
α-Amanitin is a selective inhibitor of RNA polymerase II and III but not I. [2] [3] This mechanism makes it a deadly toxin. α-Amanitin can also be used to determine which types of RNA polymerase are present. This is done by testing the sensitivity of the polymerase in the presence of α-amanitin.
RIG-I has been shown to enable breast cancer cells (BrCa) to resist treatments and grow because of an IFN response to noncoding RNA. In contrast, RIG-I in other types of cancer, such as acute myeloid leukemia and hepatocellular carcinoma, can act as a tumor suppressor. [10] If cancer causing viruses infect a cell, however, RIG-I can lead to ...
In cancer treatment, they aid cancer antigen targeting. [16] The only approved cellular cancer therapy based on dendritic cells is sipuleucel-T . One method of inducing dendritic cells to present tumor antigens is by vaccination with autologous tumor lysates [ 17 ] or short peptides (small parts of the protein that correspond to the protein ...
Transcription-mediated amplification (TMA) is an isothermal (performed at constant temperature), single-tube nucleic acid amplification system utilizing two enzymes, RNA polymerase and reverse transcriptase. "Amplification" means creating many more copies of a strand of nucleic acid than was present at first, in order to readily detect it or ...
Pages in category "RNA polymerase inhibitors" The following 5 pages are in this category, out of 5 total. This list may not reflect recent changes. A. Α-Amanitin;
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