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Methylephedrine, sold under the brand name Metheph among others, is a sympathomimetic medication described as an antiasthmatic agent and used to treat coughing and nasal congestion. [ 3 ] [ 4 ] [ 1 ] It is reported to be used in various over-the-counter cough and cold preparations throughout the world, including Japan .
Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
The AAP Red Book, or Report of the Committee on Infectious Diseases of the American Academy of Pediatrics, is a hardcover, softcover, and electronic reference to the "manifestations, etiology, epidemiology, diagnosis, and treatment of some 200 childhood infectious diseases". The Red Book first appeared as an eight-page booklet in 1938. The most ...
These recommendations are typically published in the peer-reviewed scientific journal Pediatrics. [17] [18] Previously, the AAP recommended that children remain rear-facing until they are two years of age. [17] In response to updated crash test, simulation, and field data, the AAP revised their guidance to exclude the age guideline entirely. [19]
It also includes drugs which are marketed as cough suppressants or antitussives, but their effectiveness in reducing cough symptoms is unclear or minimal. [ 1 ] [ 2 ] [ 3 ] While they have been used by 10% of American children in any given week, they are not recommended in Canada or the United States in children six years or younger because of ...
Approximately 90% of a dose of phenylpropanolamine is excreted in the urine unchanged within 24 hours. [4] [6] [7] [5] About 4% of excreted material is in the form of metabolites. [4] The elimination half-life of immediate-release phenylpropanolamine is about 4 hours, with a range in different studies of 3.7 to 4.9 hours.
While the use of inhaled steroids and long-acting beta2‑adrenergic agonists are recommended for the resulting improvement in control of symptoms of asthma, [10] concerns have been raised that salmeterol may increase the risk of death due to asthma, and this additional risk is not reduced by the addition of inhaled steroids. [11]
As a cough suppressant, the polistirex version lasts up to 12 hours. This duration also holds true when used recreationally. In 1981, a paper by Gosselin estimated that the lethal dose is between 50 and 500 mg/kg. Doses as high as 15–20 mg/kg are taken by some recreational users.