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Ringer's lactate solution has a lower rate of acidosis as compared with normal saline. [1] [4] Use is generally safe in pregnancy and breastfeeding. [2] Ringer's lactate solution is in the crystalloid family of medications. [5] It is isotonic, i.e. it has the same tonicity as blood. [2]
Ringer's solution is a solution of several salts dissolved in water for the purpose of creating an isotonic solution relative to the body fluids of an animal. Ringer's solution typically contains sodium chloride , potassium chloride , calcium chloride and sodium bicarbonate , with the last used to buffer the pH .
Lactated Ringer's solution contains 28 mmol/L lactate, 4 mmol/L K + and 1.5 mmol/L Ca 2+. It is very similar – though not identical – to Hartmann's solution , the ionic concentrations of which differ slightly.
Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as maize or beets , and then, by neutralizing the resulting lactic acid [ 4 ] to create a compound having the formula NaC 3 H 5 O 3 .
Digoxin increased the risk of death in women by 23%. There was no difference in the death rate for men in the study. [38] Digoxin is also used as a standard control substance to test for P-glycoprotein inhibition. [39] Digoxin appears to be a peripherally selective drug due to limited brain uptake caused by binding to P-glycoprotein. [40] [41]
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [ 1 ] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life .
The penny, which is made of zinc with a copper overlay, cost 3.07 cents to make in 2024, per the US Mint. A 2022 poll showed 58% of US voters wanted the government to stop production of the penny ...
ATC code B05 Blood substitutes and perfusion solutions is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.