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Fibroblast growth factor receptor 1 on the Atlas of Genetics and Oncology; FGFR1 human gene location in the UCSC Genome Browser. FGFR1 human gene details in the UCSC Genome Browser. Overview of all the structural information available in the PDB for UniProt: P11362 (Human Fibroblast growth factor receptor 1) at the PDBe-KB.
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. [ 5 ] [ 6 ] It is synthesized as a 155 amino acid polypeptide, whose mature form is a non- glycosylated 17-18 kDa protein.
A mitogenic growth factor activity was found in pituitary extracts by Armelin in 1973 [14] and further work by Gospodarowicz as reported in 1974 described a more defined isolation of proteins from cow brain extract which, when tested in a bioassay that caused fibroblasts to proliferate, led these investigators to apply the name "fibroblast ...
The fibroblast growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. These receptors bind fibroblast growth factors, members of the largest family of growth factor ligands, comprising 22 ...
Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene. [5] The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ...
A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1.
Growth factor is sometimes used interchangeably among scientists with the term cytokine. [3] Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes).
FGFR1OP2, when fused with the fibroblast growth factor receptor 1 (FGFR1), is shown to cause myeloproliferative syndrome. [1] The protein encoded by the FGFR1 gene belongs to the fibroblast growth factor receptor family. [2]