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Elevations in target cells are the result of a shift in the exchange equilibrium between the red blood cells and the cholesterol. Also, the surface membrane to volume ratio is increased. Target cells are more resistant to osmotic lysis, which is mostly seen in dogs. Hypochromic cells in iron deficiency anemias also can show a target appearance.
Blood film of hemoglobin SC disease, showing many target cells and few sickle cells HbC can combine with other abnormal hemoglobins and cause serious hemoglobinopathies. Individuals with sickle cell–hemoglobin C (HbSC), have inherited the gene for sickle cell disease (HbS) from one parent and the gene for hemoglobin C disease (HbC) from the ...
Anemia of chronic disease shows unremarkable RBCs, iron deficiency shows anisocytosis, anisochromia and elliptocytosis, and thalassemias demonstrate target cells and coarse basophilic stippling. In practice, though elliptocytes and anisocytosis are often seen in thalassemia and target cells occasionally in iron deficiency. [10]
Macrocytic anemia is a class of anemia characterized by the presence of predominantly larger-than-normal red blood cells (RBC, also known as erythrocytes) accompanied by low numbers of RBC and often also with insufficient hemoglobin content per cell. Macrocytic anemia occurs when – despite the larger cell size – such factors result in ...
Sideroblastic anemia, or sideroachrestic anemia, is a form of anemia in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). [1] In sideroblastic anemia, the body has iron available but cannot incorporate it into hemoglobin , which red blood cells need in order to transport oxygen efficiently.
Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders that are typically inherited. [2] The most common type is known as sickle cell anemia. [2] Sickle cell anemia results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2]
Normocytic anemia is the most commonly seen type of anemia. This type of anemia is usually caused by the underproduction of blood cells as well as hemolysis.Anemia can be caused by either overproduction or underproduction of red blood cells, as well as the production of defective blood cells.
Microangiopathic hemolytic anemia may be suspected based on routine medical laboratory tests such as a CBC (complete blood cell count). Automated analysers (the machines that perform routine full blood counts in most hospitals) are designed to flag blood specimens that contain abnormal amounts of red blood cell fragments or schistocytes. [2]