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The concern goes beyond ineffectiveness; phenylephrine can come with side effects such as headaches, insomnia and nervousness. At higher doses, it can increase blood pressure.
Phenylephrine is a selective α 1-adrenergic receptor agonist with minimal to no β-adrenergic receptor agonist activity or induction of norepinephrine release. [5] [8] [15] It causes constriction of both arteries and veins. [12] Phenylephrine was patented in 1933 [16] and came into medical use in 1938. [17] It is available as a generic medication.
The same vasoconstriction action can also result in hypertension, which is a noted side effect of pseudoephedrine. Pseudoephedrine can be used either as oral or as topical decongestant. Due to its stimulating qualities, however, the oral preparation is more likely to cause adverse effects, including urinary retention.
Even without phenylephrine, there are many things at the pharmacy that could help when you are feeling congested, Brodner said. He recommends a three-step plan to attack the stuffed-up feeling.
After an FDA advisory committee said the decongestant phenylephrine, ... Like phenylephrine nasal spray, prolonged use of oxymetazoline nasal spray can also cause rebound congestion. Antihistamines.
Rebound insomnia is insomnia that occurs following discontinuation of sedative substances taken to relieve primary insomnia. Regular use of these substances can cause a person to become dependent on its effects in order to fall asleep.
In addition to steroid nasal sprays and antihistamine sprays, Tracy says phenylephrine is still considered effective in nasal spray form — though Tracy warns it can be “habit-forming” if ...
Insomnia can be grouped into primary and secondary, or comorbid, insomnia. [124] [125] [126] Primary insomnia is a sleep disorder not attributable to a medical, psychiatric, or environmental cause. [127] There are three main types of primary insomnia.