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Digoxigenin is a hapten, a small molecule with high antigenicity, that is used in many molecular biology applications similarly to other popular haptens such as 2,4-Dinitrophenol, biotin, and fluorescein. Typically, digoxigenin is introduced chemically (conjugation) into biomolecules (proteins, nucleic acids) to be detected in further assays.
Women who took digoxin died "more frequently" (33%) than women who took placebo (29%). Digoxin increased the risk of death in women by 23%. There was no difference in the death rate for men in the study. [38] Digoxin is also used as a standard control substance to test for P-glycoprotein inhibition. [39] Digoxin appears to be a peripherally ...
Downhill frames are also overbuilt to handle the stress of riding over rocky terrain, drops, and jumps. Bike weights have been typically over 34 lb (15.4 kg), but modern downhill bikes have broken the 30 lb (13.6 kg) weight barrier (with some custom builds on carbon frames weighing between 27–29 lb (12–13 kg)).
Mountain biking (abbr. MTB) is a sport of riding bicycles off-road, often over rough terrain, usually using specially designed mountain bikes.Mountain bikes share similarities with other bikes but incorporate features designed to enhance durability and performance in rough terrain, such as air or coil-sprung shocks used as suspension, larger and wider wheels and tires, stronger frame materials ...
An unusual side effect of digoxin is a disturbance of color vision (mostly yellow and green) called xanthopsia. Vincent van Gogh's "Yellow Period" may have somehow been influenced by concurrent digitalis therapy. Other oculotoxic effects of digoxin include generalized blurry vision, as well as seeing a "halo" around each point of light.
Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong ...
It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. α-Acetyldigoxin increases the contractility of the heart by its positive inotropic effect on cardiac muscle . [ citation needed ] The effects of α-acetyldigoxin begin 3–4 hours after administration, and maximize after 6–8 hours.
The wheel size is sometimes erroneously called "650B" [8] [9] as a "marketing term" by some manufacturers for their 27.5", but the 650B size has traditionally been a designation for a 26 inch diameter (ISO ~ 40-584 demi-ballon tire) using the same ISO 584 mm rim [10] used by French tandems, Porteurs and touring bicycles.