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Indiana banned synthetic cannabinoids in a law which became effective in March 2012. [178] North Carolina banned synthetic cannabis mimics by a unanimous vote of the state senate, due to concerns that its contents and effects are reasonably similar to cannabis, and may cause equal effects in terms of psychological dependency. [179] [180]
4F-MDMB-BINACA (also known as MDMB-4F-BINACA, [2] 4F-MDMB-BUTINACA or 4F-ADB) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family. [3] It should not be confused with the amantadine analogue 4F-ABINACA. It has been used as an active ingredient in synthetic cannabis products and sold as a designer drug since late 2018.
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
While weed is illegal in Indiana, Delta products are legal to purchase and consume. Hemp has been legal to sell since 2018 and has very low levels of Delta-9 THC, the psychoactive compound that ...
Hexahydrocannabiphorol (HHCP, sometimes mistakenly referred to as hexahydroxycannabiphorol) is a semi-synthetic cannabinoid derivative which has been marketed since around 2021. [1] [2] It is believed to be made from the hydrogenation of tetrahydrocannabiphorol (THCP). THCP is only reported as a trace component of cannabis in 2019. [3]
ADB-BINACA (also known as ADMB-BZINACA using EMCDDA naming standards [1]) is a cannabinoid designer drug that has been found as an ingredient in some synthetic cannabis products. [2] It was originally developed by Pfizer as a potential analgesic, and is a potent agonist of the CB 1 receptor with a binding affinity (K i) of 0.33 nM and an EC 50 ...
Cannabinoids and their K i values [a]; Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x): JWH-007 [5]: Naphthoylindole: 9.5 ± 4.5
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