Ads
related to: sickle cell thalassemia symptoms- About Thalassemia
Find more information on
thalassemia & how to manage.
- Healthcare Professionals
Please visit this website if
you are a healthcare professional.
- Managing Thalassemia
There's hope for managing the
symptoms & complications.
- Thalassemia Support
Connect with a Clinical Nurse
Educator for support.
- About Thalassemia
Search results
Results From The WOW.Com Content Network
Sickle cell-beta thalassemia is an inherited blood disorder. The disease may range in severity from being relatively benign and like sickle cell trait to being similar to sickle cell disease . [ 1 ] [ 2 ]
The person has very few if any symptoms of sickle cell disease but carries the gene and can pass it on to their children. [56] Autosomal recessive inheritance means acquiring two changed genes from each parent. If both parents are carriers for the autosomal recessive gene, there is a 25% chance of their child having and expressing the disorder.
Gene therapy for hemoglobinopathies was first trialled in 2014 on a single patient with sickle cell disease (a fault in the beta globin gene), [93] and followed by clinical trials in which a number of patients with either sickle cell or beta thalassemia were successfully treated. [94]
Splenic sequestration crisis is a life-threatening illness common in pediatric patients with homozygous sickle cell disease and beta thalassemia. Up to 30% of these children may develop splenic sequestration crisis with a mortality rate of up to 15%.
The sickle cell trait provides a survival advantage against malaria fatality over people with normal hemoglobin in regions where malaria is endemic. The trait is known to cause significantly fewer deaths due to malaria, especially when Plasmodium falciparum is the causative organism.
Beta thalassemia genetics, the picture shows one example of how beta thalassemia is inherited. The beta globin gene is located on chromosome 11. A child inherits two beta globin genes (one from each parent). Specialty: Hematology: Types: Thalassemia minor, intermediate and major [2] Causes: Mutations in the HBB gene [1] Diagnostic method: DNA ...
Ads
related to: sickle cell thalassemia symptoms