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Pyruvate, the conjugate base, CH 3 COCOO −, is an intermediate in several metabolic pathways throughout the cell. Pyruvic acid can be made from glucose through glycolysis, converted back to carbohydrates (such as glucose) via gluconeogenesis, or converted to fatty acids through a reaction with acetyl-CoA. [3]
Pyruvate dehydrogenase complex reaction. Pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction (or oxidative decarboxylation of pyruvate [1]), is the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex. [2] [3] The reaction may be simplified as:
The pyruvate produced by glycolysis is an important intermediary in the conversion of carbohydrates into fatty acids and cholesterol. [46] This occurs via the conversion of pyruvate into acetyl-CoA in the mitochondrion. However, this acetyl CoA needs to be transported into cytosol where the synthesis of fatty acids and cholesterol occurs.
The pyruvate is turned into 2 lactate molecules, which convert NADH back to NAD+. The process then repeats, starting with another glucose molecule. Lactic acid fermentation is a metabolic process by which glucose or other six-carbon sugars (also, disaccharides of six-carbon sugars, e.g. sucrose or lactose ) are converted into cellular energy ...
Pyruvate is the terminal electron acceptor in lactic acid fermentation. When sufficient oxygen is not present in the muscle cells for further oxidation of pyruvate and NADH produced in glycolysis, NAD+ is regenerated from NADH by reduction of pyruvate to lactate. [4] Lactate is converted to pyruvate by the enzyme lactate dehydrogenase. [3]
Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. [1] Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration , and this complex links the glycolysis metabolic pathway to the citric acid cycle .
CH 3 COCOO − is pyruvate, and P i is inorganic phosphate. Finally, pyruvate is converted to ethanol and CO 2 in two steps, regenerating oxidized NAD+ needed for glycolysis: 1. CH 3 COCOO − + H + → CH 3 CHO + CO 2. catalyzed by pyruvate decarboxylase. 2. CH 3 CHO + NADH + H + → C 2 H 5 OH + NAD + This reaction is catalyzed by alcohol ...
Pyruvate decarboxylase is an enzyme (EC 4.1.1.1) that catalyses the decarboxylation of pyruvic acid to acetaldehyde. It is also called 2-oxo-acid carboxylase, alpha-ketoacid carboxylase, and pyruvic decarboxylase. [ 1 ]