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Erythropoiesis-stimulating agents (ESA) are medications which stimulate the bone marrow to make red blood cells. [1] They are used to treat anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in HIV/AIDS. [1] [2] In these situations they decrease the need for blood transfusions. [2]
The main criterion is that other causes of anemia have also been investigated, such as vitamin B 12 or folate deficiency, drug induced or due to other poisons such as lead, as often the anemia has more than one underlying cause. [19] Iron deficiency anemia is classically a microcytic, hypochromic anemia.
Molidustat is a drug which acts as an HIF prolyl-hydroxylase inhibitor and thereby increases endogenous production of erythropoietin, which stimulates production of hemoglobin and red blood cells. It is in Phase III clinical trials for the treatment of anemia caused by chronic kidney disease .
Anemia, or the low count of red blood cells, is a common complication of CKD, a condition in which a person's kidneys cannot filter blood efficiently, causing waste and fluid to build up in the body.
The types of anemia treated with drugs are iron-deficiency anemia, thalassemia, aplastic anemia, hemolytic anemia, sickle cell anemia, and pernicious anemia, the most important of them being deficiency and sickle cell anemia with together 60% of market share because of highest prevalence as well as higher treatment costs compared with other ...
Daprodustat, sold under the brand name Duvroq among others, is a medication that is used for the treatment of anemia due to chronic kidney disease. [2] It is a hypoxia-inducible factor prolyl hydroxylase inhibitor. [2] It is taken by mouth. [2] [3] [4]
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