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Common side effects include headache, joint pain, and injection site reactions including pain. [7]In one trial, more patients in the romosozumab group had serious cardiovascular events compared to the alendronate group (0.8% vs 0.3%), [13] though this was not found in a trial of romosozumab vs placebo. [14]
These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone [3] and Duchenne muscular dystrophy (DMD). It is given by injection into a vein. [3] Common side effects include fever, joint pain, high blood pressure, diarrhea, and feeling tired. [3]
Common side effects (1 to 10% of patients) include constipation, abdominal pain, nausea, and acid reflux. [4] Use is not recommended during pregnancy or in those with poor kidney function. [5] Alendronic acid works by decreasing the activity of cells that break down bone. [4]
Abaloparatide, sold under the brand name Tymlos among others, is a parathyroid hormone-related protein (PTHrP) analog medication used to treat osteoporosis. [2] It is an anabolic (i.e., bone growing) agent. [4] The most common side effects include hypercalciuria (high calcium levels in the urine) and dizziness. [3]
Bisphosphonates are used to treat osteoporosis, osteitis deformans (Paget's disease of the bone), bone metastasis (with or without hypercalcemia), multiple myeloma, and other conditions involving fragile, breakable bone. In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate and risedronate.
[3] [55] Due to its strong antigonadotropic effects and suppression of androgen and estrogen levels, CPA is associated with marked sexual dysfunction (including loss of libido and impotence) similar to that seen with castration, [37] [18] [97] and osteoporosis, [98] whereas such side effects occur minimally with NSAAs like bicalutamide.
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